Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

Daniel Szczerba, Davin Tan, Jean-Louis Do, Hatem M. Titi, Siham Mouhtadi, Denis Chaumont, Maria del Carmen Marco de Lucas, Nicolas Geoffroy, Michel Meyer, Yoann Rousselin, Jessica M. Hudspeth, Valerie Schwanen, Petra Spörk-Erdely, Ann-Christin Dippel, Oleh Ivashko, Olof Gutowski, Philipp Glaevecke, Vasilii Bazhenov, Mihails Arhangelskis, Ivan HalaszTomislav Friscic, Simon A.J. Kimber

Publikation: Beitrag in FachzeitschriftArtikelForschungBegutachtung

Abstract

Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.

OriginalspracheEnglisch
Seiten (von - bis)16332-16336
Seitenumfang5
FachzeitschriftJournal of the American Chemical Society
Jahrgang143.2021
Ausgabenummer40
Frühes Online-Datum28 Sept. 2021
DOIs
PublikationsstatusVeröffentlicht - 13 Okt. 2021

Bibliographische Notiz

Funding Information:
We acknowledge the European Synchrotron Radiation Facility for provision of synchrotron beam time on ID15B. We acknowledge DESY (Hamburg, Germany), a member of the Helmholtz Association HGF, for the provision of experimental facilities. Parts of this research were carried out at P21.1. We thank Sakura Pascarelli for her kind help in Hamburg and the staff of ID15 at the ESRF for assistance with consumables. Agnieszka Poulain is acknowledged for support on the beamline. V.S. and P.S.-E. were funded by the ESRF-ILL International Summer Student Program. This work was supported by the EIPHI Graduate School (contract ANR-17-EURE-0002). Ce travail a été soutenu par le programme ”Investissements d’Avenir”, ISITE-BFC project (contract ANR- 15-IDEX-0003). We thank Agnès Birot for administrative support.

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