The “wind tunnel” approach is applied to study high-speed train aerodynamics in a railway tunnel using FDS software. The main focus of the research is on the pressure distribution along the tunnel. Proven analytical dependencies based on the experimental observations for air jet centerline velocity and flow entrainment are used to evaluate the model setup. A model verification is carried out based on the pressure drop calculations due to viscous effects where the impact of the surface roughness and the tunnel length are also considered. A sensitivity analysis is performed to evaluate changes in input FDS parameters and to explore interactions between them. It is proposed to use the standard deviation, obtained from the calculated time-averaged pressure values, to specify the appropriate numeric parameter combinations, e.g. DT and PRESSURE_TOLERANCE, considering the desired results consistency and the computational time consumed. The simulated cases with and without a train inside a tunnel provide data on the aerodynamic characteristics of the models. The obtained volumetric and cross-sectional profiles for pressure and airflow velocity distribution form the basis for an informed decision regarding the tunnel design or safety solutions, for example, defining areas under maximal and minimal pressure loads. The analysis displays the necessity to carefully manage each investigated case considering the FDS features and limitations that largely affect a model setup and calculations.