Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

Daniel Szczerba; Davin Tan; Jean-Louis Do; Hatem M. Titi; Siham Mouhtadi; Denis Chaumont; Maria del Carmen Marco de Lucas; Nicolas Geoffroy; Michel Meyer; Yoann Rousselin; Jessica M. Hudspeth; Valerie Schwanen; Petra Spörk-Erdely; Ann-Christin Dippel; Oleh Ivashko; Olof Gutowski; Philipp Glaevecke; Vasilii Bazhenov; Mihails Arhangelskis; Ivan Halasz; Tomislav Friscic; Simon A.J. Kimber

doi:10.1021/jacs.1c07186

Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

Daniel Szczerba, Davin Tan, Jean-Louis Do, Hatem M. Titi, Siham Mouhtadi, Denis Chaumont, Maria del Carmen Marco de Lucas, Nicolas Geoffroy, Michel Meyer, Yoann Rousselin, Jessica M. Hudspeth, Valerie Schwanen, Petra Spörk-Erdely, Ann-Christin Dippel, Oleh Ivashko, Olof Gutowski, Philipp Glaevecke, Vasilii Bazhenov, Mihails Arhangelskis, Ivan HalaszTomislav Friscic, Simon A.J. Kimber

Chair of Physical Metallurgy (420)

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.

Original language	English
Pages (from-to)	16332-16336
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	143.2021
Issue number	40
Early online date	28 Sept 2021
DOIs	https://doi.org/10.1021/jacs.1c07186
Publication status	Published - 13 Oct 2021

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Szczerba, D., Tan, D., Do, J.-L., Titi, H. M., Mouhtadi, S., Chaumont, D., Marco de Lucas, M. D. C., Geoffroy, N., Meyer, M., Rousselin, Y., Hudspeth, J. M., Schwanen, V., Spörk-Erdely, P., Dippel, A.-C., Ivashko, O., Gutowski, O., Glaevecke, P., Bazhenov, V., Arhangelskis, M., ... Kimber, S. A. J. (2021). Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate. Journal of the American Chemical Society, 143.2021(40), 16332-16336. https://doi.org/10.1021/jacs.1c07186

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title = "Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate",

abstract = "Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such {"}magic-size{"}clusters can be both stable enough to crystallize and sufficiently labile for further growth.",

author = "Daniel Szczerba and Davin Tan and Jean-Louis Do and Titi, {Hatem M.} and Siham Mouhtadi and Denis Chaumont and {Marco de Lucas}, {Maria del Carmen} and Nicolas Geoffroy and Michel Meyer and Yoann Rousselin and Hudspeth, {Jessica M.} and Valerie Schwanen and Petra Sp{\"o}rk-Erdely and Ann-Christin Dippel and Oleh Ivashko and Olof Gutowski and Philipp Glaevecke and Vasilii Bazhenov and Mihails Arhangelskis and Ivan Halasz and Tomislav Friscic and Kimber, {Simon A.J.}",

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doi = "10.1021/jacs.1c07186",

language = "English",

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Szczerba, D, Tan, D, Do, J-L, Titi, HM, Mouhtadi, S, Chaumont, D, Marco de Lucas, MDC, Geoffroy, N, Meyer, M, Rousselin, Y, Hudspeth, JM, Schwanen, V, Spörk-Erdely, P, Dippel, A-C, Ivashko, O, Gutowski, O, Glaevecke, P, Bazhenov, V, Arhangelskis, M, Halasz, I, Friscic, T & Kimber, SAJ 2021, 'Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate', Journal of the American Chemical Society, vol. 143.2021, no. 40, pp. 16332-16336. https://doi.org/10.1021/jacs.1c07186

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T1 - Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

AU - Szczerba, Daniel

AU - Tan, Davin

AU - Do, Jean-Louis

AU - Titi, Hatem M.

AU - Mouhtadi, Siham

AU - Chaumont, Denis

AU - Marco de Lucas, Maria del Carmen

AU - Geoffroy, Nicolas

AU - Meyer, Michel

AU - Rousselin, Yoann

AU - Hudspeth, Jessica M.

AU - Schwanen, Valerie

AU - Spörk-Erdely, Petra

AU - Dippel, Ann-Christin

AU - Ivashko, Oleh

AU - Gutowski, Olof

AU - Glaevecke, Philipp

AU - Bazhenov, Vasilii

AU - Arhangelskis, Mihails

AU - Halasz, Ivan

AU - Friscic, Tomislav

AU - Kimber, Simon A.J.

PY - 2021/10/13

Y1 - 2021/10/13

N2 - Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.

AB - Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi9O7} and {Bi38O44}, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi3+ displacements. This explains why such "magic-size"clusters can be both stable enough to crystallize and sufficiently labile for further growth.

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M3 - Article

SN - 0002-7863

VL - 143.2021

SP - 16332

EP - 16336

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 40

ER -

Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate

Abstract

Bibliographical note

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